ABSTRACT
Rural coexistence for many people is associated with living in a constant disadvantage, which has increased with the emergence of the pandemic generated by covid-19, for this reason we seek to give an interpretation to the behavior presented by the study group. For the purposes of the research work, the multivariate statistical technique of Discriminant Analysis was used, applied to a group of variables in two surveys conducted to those who make up the working population, emphasizing that the questionnaires refer to two different periods of time, where it was found that for reasons of the scenario in which they perform their activities, the vast majority fails to have the right lifestyle, The same gains more value from comments made by the population, where they highlight aspects such as the high crime rate, the low degree of professionalization, abuse by third parties, and the growing difficulty to mitigate this social crisis given the lack of labor supply, because the employed people fulfill their working hours, but do not enjoy a fixed working day with a constant and adequate remuneration, in addition to the benefits that a job in a dependent relationship could give them. © 2022, Associacao Iberica de Sistemas e Tecnologias de Informacao. All rights reserved.
ABSTRACT
In General, the agricultural and labor activity of the Chobo parish, for many scarce resources families represents their only source of subsistence, which has been strongly affected with the arrival of covid-19, for this reason it seeks to analyze how this labor sector was affected. In this research, the multivariate statistical technique of principal component analysis was applied to a set of variables corresponding to two surveys located in two different time spaces on a part of the working population, where it is highlighted that people do not have the facilities to be able to develop their activity, the same thing that is more evidenced by the opinions of the inhabitants, the low professionalization of the field, and the difficulty of being able to establish themselves in a position that gives them good benefits, given that many fulfill their functions under very variable working days. © 2022, Associacao Iberica de Sistemas e Tecnologias de Informacao. All rights reserved.
ABSTRACT
The labor activity of Milagro city is preceded in many cases by agriculture, representing at the same time as the only source of income for the large number of people who inhabit these areas, which has also been affected to some extent by the appearance of the covid-19 virus, for this reason the possibility of analyzing the degree of influence of this situation on the labor sector is raised. In this research work, the statistical methodology of Analysis by Canonical Correlations was used, to a set of variables located in two different periods of time on the people who exercise some activity within the labor field, where the difficulties that they present are highlighted re-flected mainly in the delicate economic situation that they demonstrated to have. In addition, the collection of different points of view summarizes how complica-ted it is to be able to get a good workplace, which provides them with better benefits, given that in most cases their work is compromised by the variability of working hours, the lack of insurance, and the cons-tant challenges of living in rural areas.
ABSTRACT
Background: The management of acute myeloid leukemia (AML) patients usually requires long inpatient treatments that can affect the limited care facilities, the quality of life, and increases healthcare costs. Additionally, leukemia treating centers in developing countries face limited sources to deliver high-dose chemotherapies as inpatient treatments. Therefore, several reports have established the feasibility and safety of outpatient consolidation. We aimed to implement a high-dose cytarabine outpatient program for AML in a limited-source institution at a public center in Peru.Methods: We conducted a prospective pilot study starting in January 2019 and ending before the COVID-19 Pandemic in March 2020. Eligible patients were ≥ age 14, met inclusion criteria for inpatient induction regimens, were without active infection, and had the following: normal chest x-ray and biochemistry, complete remission after one cycle of 7+3 induction. Logistical requirements included a 3-hours distance residence near the treatment center, caregiver support, trained nursing staff, infusion room capacity, and participation in follow-up. Patients received prophylactic antimicrobials such as oral levofloxacin, fluconazole, and acyclovir and were admitted to the hospital for predetermined complications of therapy (fever, G3-4 toxicity, febrile neutropenia, bleeding or refractory thrombocytopenia). Risk stratification was based on conventional cytogenetics and multiplex PCR using Leukemia.net criteria. Results: Forty-two patients were included during the study period. The median age was 38 years (16-63) and Female/Male ratio 4:3. According to Leukemia.net, 24% were classified as high, 50% intermediate and 26% as low risk group. Including FLT3 mutations in 26% of cases. Twenty-two and 20 subjects received 1-2 and 3-4 cycles of ambulatory HiDAC, respectively. About one-third of cases had emergency admissions during consolidation and 74% complete at least 3 cycles of cytarabine. Only 4 patients underwent sibling-donor allo-SCT. Sixty-four percent experienced relapses, and at 2 years follow-up only 21 subjects were alive. Median OS was 15 months, a better survival was shown among patients who received 3-4 cycles of ambulatory HiDAC (2-year OS 18 vs 23%, p=0.031). Conclusion: Our pilot study shows the feasibility to deliver HiDAC as outpatient consolidation in selected AML cases in a limited setting. Additionally, a high rate of relapses and poor survival was noted in our cohort that requires further consideration. Disclosures: No relevant conflicts of interest to declare.